UFGI Publication Round-Up: Week of 12/22/2025

Brewer MK, Donohue KJ, Singh PK, Raththagala M, Simmons ZR, Wayne JL, Li S, Viana R, Segvich DM, Contreras CJ, Cantrell AR, Sanz P, Sun RC, Vander Kooi CW, Roach PJ, DePaoli-Roach A, Gentry MS.

J Biol Chem. 2025 Dec 22:111097. doi: 10.1016/j.jbc.2025.111097. Online ahead of print.

PMID: 41443417

Clinical Manifestations.

Schade RN, O’Shea A, Rodriguez K, Gertler J, Huo Z, DeKosky ST, Woods AJ, Alexander G, Bowers D.

Alzheimers Dement. 2025 Dec;21 Suppl 3(Suppl 3):e103370. doi: 10.1002/alz70857_103370.

PMID: 41447509

Repeat-associated non-AUG translation as a common mechanism for the polyGln ataxias.

Banez-Coronel M, Zu T, Aldridge M, Guo S, Ajredini R, Morrison D, Tays AB, Duvick LA, Pletnikova O, Yachnis AT, Troncoso JC, Paulson HL, McLoughlin HS, Ashizawa T, Subramony SH, Orr HT, Ranum LPW.

Cell Rep. 2025 Dec 19;45(1):116741. doi: 10.1016/j.celrep.2025.116741. Online ahead of print.

PMID: 41422503

Basic Science and Pathogenesis.

Phuong HT, Tomas RF, Akamese C, Mijares A, Guo S, Bell LR, Yegorova S, Ng SK, Phillips JL, Melloni AN, Pletnikova O, Clark HB, Troncoso JC, Hyman BT, Ranum LPW, Prokop S, Nguyen L.

Alzheimers Dement. 2025 Dec;21 Suppl 1(Suppl 1):e101865. doi: 10.1002/alz70855_101865.

PMID: 41436163

Basic Science and Pathogenesis.

Akmese C, Tomas RF, Phuong HT, Mijares A, Guo S, Bell LR, Yegorova S, Ng SK, Phillips JL, Melloni AN, Pletnikova O, Clark HB, Troncoso JC, Hyman BT, Ranum LPW, Prokop S, Nguyen L.

Alzheimers Dement. 2025 Dec;21 Suppl 1(Suppl 1):e105969. doi: 10.1002/alz70855_105969.

PMID: 41442659

A Cold Stress-Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor.

Zhou J, Chen J, Zhang H, Guo L, Mai K, Abraham E, Prajapati DV, Chang Y, Ning J, Wang X, Li D, Zhang DD, Sun J, Butcher RA, Zhao L.

Adv Sci (Weinh). 2025 Dec 22:e09822. doi: 10.1002/advs.202509822. Online ahead of print.

PMID: 41431176

Ablation of mitochondrial calcium uniporter alleviates cardiac dysfunction in type 1 diabetes.

Deb A, Gomez V, Cheng Y, Li Z, Yang J, Dowllah I, Nguyen N, Adekanye O, Smuder AJ, Cheng Z, Liu B.

Cell Calcium. 2025 Dec 17;133:103106. doi: 10.1016/j.ceca.2025.103106. Online ahead of print.

PMID: 41442803

Basic Science and Pathogenesis.

Suárez A, Melloni AN, Hyman BT, Nguyen L.

Alzheimers Dement. 2025 Dec;21 Suppl 1(Suppl 1):e102945. doi: 10.1002/alz70855_102945.

PMID: 41437291

Basic Science and Pathogenesis.

Tomas RF, Phuong HT, Bell LR, Akamese C, Nguyen L.

Alzheimers Dement. 2025 Dec;21 Suppl 1(Suppl 1):e102925. doi: 10.1002/alz70855_102925.

PMID: 41437833

Maternal diet shapes milk bile acids to regulate neonatal growth through TGR5.

Phophi L, Wilt HM, Hu Z, Gadikota R, Cadiz M, Manzi MS, Ortiz Martinez FD, Vanga S, Chapman EG, Tibbetts SA, Karst SM.

Cell Rep. 2025 Dec 24;45(1):116744. doi: 10.1016/j.celrep.2025.116744. Online ahead of print.

PMID: 41447527

The METTL3-YTHDC1 axis mediates architectural RNA m⁶A modification to modulate the integrity of chromatin TADs in MLLr + AML genome.

Fu R, Yu W, Zhao R, Yang H, Cao B, Dai C, Qianjiang H, Xia Y, Wang L, Lu J, Zhou R, Shi A, Lou H, Zhang X, Luo H.

Mol Cancer. 2025 Dec 22. doi: 10.1186/s12943-025-02545-x. Online ahead of print.

PMID: 41430607

Alzheimer’s Imaging Consortium.

Blazhenets G, Snyder HM, Apostolova LG, Asken BM, Bejanin A, Bombois S, Bourgeat P, Braskie MN, Carrillo MC, Casaletto KB, Cash DM, Chang CC, Chang HI, Chao Y, Chételat G, Coath W, Collij LE, Colmant L, Dickerson BC, Dubois B, Valdez AF, Farrar G, Fortea J, Frisoni GB, Gardner RC, Garibotto V, Gu Y, Guo T, Hanseeuw BJ, Hansson O, Harrison TM, Huang Q, Huang SH, Ishii K, Ishii K, Jagust WJ, Kato T, Koeppe RA, Kramer JH, Landau SM, Landeau B, Lee S, Lopresti BJ, Lowe VJ, Mao X, March A, Masters CL, Mézenge F, Mormino EC, Franquesa-Mullerat M, Nakamura A, O’Bryant SE, Pappas I, Peretti DE, Quenon L, Rowe CC, Salvadó G, Schott JM, Schwartz D, Schwarz CG, Seo SW, Shekari M, Silbert LC, Smith R, Sokolowski A, Soleimani-Meigooni DN, Sperling RA, Sun P, Toga AW, Vaillancourt DE, van de Giessen E, van der Flier WM, Vemuri P, Villain N, Villemagne VL, Villeneuve S, Wang WE, Weiner MSW, Xiao C, Xie F, Yoon Y, Young CB, Yun M, Rabinovici GD, Joie R.

Alzheimers Dement. 2025 Dec;21 Suppl 8(Suppl 8):e110011. doi: 10.1002/alz70862_110011.

PMID: 41433809

Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability.

Huang M, Chen Y, Liang C, Narayan OP, Stallings C, Yu M, Traugot C, Li L, Li K, Vo Q, Wang H, Chou YT, Cech L, Parra D, Garzon L, Parsons D, Diaz E, Zhang C, Mackey C, Sussman H, Zmirska I, Chung M, Zhou C, Glynatsis G, Siemann DW, Licht JD, Li C, Kaye FJ, Xie M, Tan Y, Wu L, Bivona TG, Guan J, Tang X.

Biomaterials. 2025 Dec 15;329:123920. doi: 10.1016/j.biomaterials.2025.123920. Online ahead of print.

PMID: 41443038

Biomarkers.

Busch TA, Iversen K, Stolte S, Hart G, Chen J, Shukla P, Pedersen S, O’Shea A, Dai Y, Albizu A, Woods AJ, Fang R, Indahlastari A.

Alzheimers Dement. 2025 Dec;21 Suppl 2(Suppl 2):e103172. doi: 10.1002/alz70856_103172.

PMID: 41452031

Targeted Protein Degradation of the Latency-Associated Nuclear Antigen Evicts Kaposi Sarcoma-Associated Herpesvirus Episomes From Infected Cells In Vitro.

McMahon S, Amer M, Hall B, Shekhar R, Renne R.

J Med Virol. 2025 Dec;97(12):e70765. doi: 10.1002/jmv.70765.

PMID: 41431365

Basic Science and Pathogenesis.

Vo Q, Nacionales D, Biswas K, Gorski C, Moldawer LL, Efron PA, Chakrabarty P.

Alzheimers Dement. 2025 Dec;21 Suppl 1(Suppl 1):e107400. doi: 10.1002/alz70855_107400.

PMID: 41447350

Gut plasma membrane proteomes of adults and larvae of the European honey bee, Apis mellifera.

Arora AK, Mishra R, Bonning BC.

Sci Rep. 2025 Dec 26. doi: 10.1038/s41598-025-26662-1. Online ahead of print.

PMID: 41453998

Neurotoxicity Assessment of Perfluoroundecanoic Acid (PFUnDA) in Developing Zebrafish (Danio rerio).

Avidan L, English CD, Ivantsova E, Sultan A, Martyniuk CJ.

Toxics. 2025 Nov 22;13(12):1012. doi: 10.3390/toxics13121012.

PMID: 41441233

Fire intensity effects on flowering and post-fire bud activity in the endemic savanna bunchgrass Aristida beyrichiana.

Fill JM, Zee A, Love DT, Liu T, Crandall RM.

Plant Biol (Stuttg). 2025 Dec 22. doi: 10.1111/plb.70159. Online ahead of print.

PMID: 41428462

3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes.

Rippa A, Posgai AL, Currlin S, Brusko M, Williams MD, Kaddis JS, Kusmartseva I, Wasserfall CH, Campbell-Thompson M, Atkinson MA.

Nat Commun. 2025 Dec 11;16(1):11379. doi: 10.1038/s41467-025-66198-6.

PMID: 41381473

Real-World Dosing and Persistence of Oral Treprostinil Initiation Strategies in Patients With Pulmonary Arterial Hypertension.

Lachant DJ, Ataya A, James Ford H 3rd, Broderick M, Seaman S, Wu B, Chakinala MM.

Pulm Circ. 2025 Dec 19;15(4):e70227. doi: 10.1002/pul2.70227. eCollection 2025 Oct.

PMID: 41426513

Role of Sclerotherapy in Treating Oral Vascular Malformations in Hereditary Hemorrhagic Telangiectasia.

Adelman AE, Joshi A, Gallo K, Prosser A, Mathavan A, Mathavan A, Ataya A, Justice J.

Otolaryngol Head Neck Surg. 2025 Dec 26. doi: 10.1002/ohn.70088. Online ahead of print.

PMID: 41451697

Discovery of BE2012, a First-in-Class REV-ERBα/β Antagonist with Favorable Selectivity and Pharmacokinetics, and In Vivo Efficacy in Inducing Key Myogenic Factors for Muscle Repair upon Acute Muscle Injury.

Maram L, Valfort AC, Homaidur Rahman M, Okda HE, Elagawany M, Politte H, Appourchaux K, Bedia-Diaz G, Côté I, Hegazy L, Burris TP, Elgendy B.

J Med Chem. 2025 Dec 23. doi: 10.1021/acs.jmedchem.5c02749. Online ahead of print.

PMID: 41432990