UFGI Publication Round-Up: Week of 11/17/2025

UFGI Publication Round-Up: Week of 11/17/2025

Discovery of CRBN-recruiting PROTAC degraders of the METTL3-METTL14 complex.

Smith AR, Nar R, Li Y, Gour A, Sharma A, Qian Z, Zheng G, Wu Z.

Med Chem Res. 2025;34(11):2299-2308. doi: 10.1007/s00044-025-03464-8. Epub 2025 Sep 5.

PMID: 41245600

 

 

Real-world analysis of cardiovascular adverse events and risk factors after immune checkpoint inhibitor therapy.

Wang Y, Niu S, Doonan BP, Guha A, Fradley M, Wu Y, Smith SM, Gong Y, Song Q.

Cardiooncology. 2025 Nov 17;11(1):107. doi: 10.1186/s40959-025-00406-6.

PMID: 41250252

 

 

Author Correction: Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.

De Jesus DF, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN.

Nat Cell Biol. 2025 Nov 17. doi: 10.1038/s41556-025-01836-1. Online ahead of print.

PMID: 41249573

 

 

Treatment Modalities, Pain Response, and Referrals for Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: A Retrospective Study.

Wilson FC, Bruno KA, Fairweather D, Carroll MG, Darakjian AA, Gajarawala S, Zeman AM, Shirey D Jr, Buck TR, Bruce BK, Gehin JM, Boucher LM, Greenaway MS, Shufelt CL, Knight DRT.

Mayo Clin Proc Innov Qual Outcomes. 2025 Oct 31;9(6):100672. doi: 10.1016/j.mayocpiqo.2025.100672. eCollection 2025 Dec.

PMID: 41244748

 

 

Comparative assessment of left common iliac vein compression in patients with hypermobile Ehlers-Danlos syndrome, hypermobility spectrum disorder and healthy controls – A retrospective single-centre study.

Ogunlade SB, Brown D, Rozen T, Lewis AR, Toskich BB, Fairweather D, Bruno KA, Knight D, Devcic Z.

Phlebology. 2025 Nov 17:2683555251400392. doi: 10.1177/02683555251400392. Online ahead of print.

PMID: 41250613

 

 

Lipidomic Markers of Processed Meat and Unprocessed Red Meat Intake and Risk of Diabetes in American Indians.

Wen X, Miao G, Fretts AM, Chen M, Zhang Y, Umans JG, Cole SA, Best LG, Fiehn O, Zhao J.

Diabetes Care. 2025 Dec 1;48(12):2021-2030. doi: 10.2337/dc24-2828.

PMID: 40267348

 

 

Cell type-specific inference from bulk RNA-sequencing data by integrating single-cell reference profiles via EPIC-unmix.

Tang C, Sun Q, Zeng X, Li G, Yang X, Liu F, Zhao J, Shen Y, Liu B, Wen J, Li Y.

Genome Biol. 2025 Nov 20;26(1):395. doi: 10.1186/s13059-025-03847-5.

PMID: 41267097

 

 

Parkinson’s-Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa.

Mark JR, Staley HA, Titus AM, Agin-Liebes J, Garrido A, Hughes L, Dzamko N, Wallings RL, Tansey MG.

Mov Disord. 2025 Nov 19. doi: 10.1002/mds.70123. Online ahead of print.

PMID: 41257354

 

 

Trauma-induced alterations in bone marrow exosome microRNA profiles.

Yoham AL, Peethala A, Bible LE, Kannan KB, Wheeler C, Hernández-Ríos M, Rodhouse CE, Maile R, Efron PA, Mohr AM.

J Trauma Acute Care Surg. 2025 Nov 12. doi: 10.1097/TA.0000000000004831. Online ahead of print.

PMID: 41247314

 

 

HLA-B Alleles With Shared Peptide Binding Specificities Define Global Risk of Co-trimoxazole-Induced Severe Cutaneous Adverse Drug Reactions.

Li Y, Gibson A, Saeed HN, Ashraf M, Li D, Ostrov DA, Krantz MS, Mallal SA, Alves E, Chopra A, Choo L, Dodiuk-Gad RP, Kaffenberger B, Drucker AM, Goh MS, Ergen E, Micheletti R, Rosenbach M, Martin-Pozo MD, Gangula R, Williams EA, Yu A, O’Connor A, Mahan K, Kwan JT, Metcalfe D, Rashad R, Shanbhag SS, Tahboub MA, Pedretti S, Choshi P, Chimbetete T, Selim R, James I, Trubiano JA, Lehloenya R, Peter JG, Phillips EJ; SJS Survivor Study.

J Allergy Clin Immunol Pract. 2025 Nov;13(11):3042-3053. doi: 10.1016/j.jaip.2025.08.001. Epub 2025 Aug 8.

PMID: 40784610

 

 

Programmable fluorescent aptamer-based RNA switches for rapid identification of point mutations.

Yan Z, Li Y, Eshed A, Wu K, Ticktin ZM, Murugan V, Lim ES, Hong F, Green AA.

Nat Chem. 2025 Nov 21. doi: 10.1038/s41557-025-01995-6. Online ahead of print.

PMID: 41272150

 

 

Programmable fluorescent aptamer-based RNA switches for rapid identification of point mutations.

Yan Z, Li Y, Eshed A, Wu K, Ticktin ZM, Murugan V, Lim ES, Hong F, Green AA.

Nat Chem. 2025 Nov 21. doi: 10.1038/s41557-025-01995-6. Online ahead of print.

PMID: 41272150

 

 

The Hydractinia Genome Project Portal: multi-omic annotation and visualization of Hydractinia genomic datasets.

Moreland RT, Schnitzler CE, Zhang S, Singh S, Wolfsberg TG, Baxevanis AD.

Bioinform Adv. 2025 Oct 15;5(1):vbaf215. doi: 10.1093/bioadv/vbaf215. eCollection 2025.

PMID: 41262968

 

 

Comparative BMI-z Changes With Initiation and Adherence to Antidepressant Medications Among Youth.

Rifas-Shiman SL, Young J, Yu H, Daley MF, Heerman WJ, Janicke DM, Jones WS, Lewis KH, Lin PD, Prentice C, Bailey LC, Toh S, Petimar J, Block JP.

J Am Acad Child Adolesc Psychiatry. 2025 Nov 20:S0890-8567(25)02188-4. doi: 10.1016/j.jaac.2025.11.008. Online ahead of print.

PMID: 41274552

 

 

Centuries of compounding human influence on Amazonian forests.

McMichael CNH, Bush MB, Ter Steege H, Piperno DR, Gosling WD, Nascimento MN, Lombardo U, de Souza Coelho L, Leão do Amaral I, de Almeida Matos FD, de Andrade Lima Filho D, Castilho CV, Wittmann F, Guevara-Andino JE, Magnusson WE, Salomão RP, Phillips OL, Cardenas Revilla JD, Irume MV, Pires Martins M, Fernandez Piedade MT, Ferreira Ramos J, Pitman NCA, Luize BG, Moraes de Leão Novo EM, Núñez Vargas P, Sanna Freire Silva T, Martins Venticinque E, Manzatto AG, Farias Costa Reis N, Casula KR, Honorio Coronado EN, Montero JC, Schöngart J, Castaño Arboleda N, Monteagudo Mendoza A, Zartman CE, Vasquez R, Mostacedo B, Terborgh J, Demarchi LO, Assis RL, Brilhante de Medeiro M, Costa Quaresma A, Simon MF, Andrade A, Camargo JL, Feldpausch TR, Killeen TJ, Laurance WF, Laurance SGW, Maniguaje Rincón L, de Sousa Farias E, Nascimento HEM, Barçante Ladvocat Cintra B, Baker TR, Oliveira Feitosa Y, Mogollón HF, Araujo-Murakami A, Brienen R, Lopes MA, Lima Magalhães JL, Lima de Queiroz H, Comiskey JA, Marimon BS, Marimon-Junior BH, Damasco G, Draper FC, García-Villacorta R, Lopes A, Vicentini A, Cornejo Valverde F, Alonso A, Dallmeier F, Ferreira LV, Gomes VHF, P de Aguiar DP, Carvalho FA, Gribel R, Petratti Pansonato M, Aymard C GA, Fine PVA, Licona JC, Villa Zegarra BE, Vos VA, Arroyo L, Cerón C, Silveira M, Stropp J, Daly D, Milliken W, Pardo Molina G, Ríos Paredes M, Barlow J, Berenguer E, Dantas do Amaral D, Ferreira J, Jimenez EM, Klitgaard B, Mora MCP, Peres CA, Stevenson PR, Dexter KG, Di Fiore A, Huamantupa-Chuquimaco I, Marcelo Pena JL, Pennington T, de Oliveira Pereira L, Phillips JF, Rivas-Torres G, Hildebrand PV, Costa Noronha J, Marques Barbosa E, Rodrigues Barbosa F, de Matos Bonates LC, de Sá Carpandeo R, Dávila Doza HP, Fuentes A, Zárate Gómez R, Gonzales T, Gallardo Gonzales GP, Malhi Y, de Andrade Miranda IP, Mozombite Pinto LF, Prieto A, Rodrigues DJ, Rudas A, Tello JS, Vela CIA, Albuquerque BW, Cano A, Holmgren M, Trindade Nascimento M, Oliveira AA, Rocha M, Ruschel AR, Vizoni Scudeller V, Sierra R, Silman MR, Silva N, Tirado M, Umaña MN, Vriesendorp C, Baider C, Balslev H, Linares-Palomino R, Mendoza C, Mesones I, Parada GA, Alexiades MN, Farfan-Rios W, Garcia-Cabrera K, Palacios Cuenca W, Pansini S, Pauletto D, Ramirez Arevalo F, Sampaio AF, Valderrama Sandoval EH, Valenzuela Gamarra L, Veiga Carim MJ, da Silva Guimarães JR, Pipoly JJ 3rd, Coelho de Souza F, Carneiro Guedes M, de Toledo JJ, Campelo W, Henkel TW, Molino JF, Barbosa Pedrosa Costa J, Guimarães Vieira IC, Sabatier D, Duque A, Zuleta D, Trindade T, Tamanaha EK, de Almeida FO, Feeley KJ.

Proc Natl Acad Sci U S A. 2025 Nov 25;122(47):e2514040122. doi: 10.1073/pnas.2514040122. Epub 2025 Nov 17.

PMID: 41248280

 

 

Flexible oocyte manipulation with delayed maturation and improved somatic cell nuclear transfer efficiency using induced pluripotent stem cells.

de Aguiar LH, Lee YL, Abdelhady AW, Koganti PP, Selvaraj V, Cheong SH.

Theriogenology. 2025 Nov 13;251:117754. doi: 10.1016/j.theriogenology.2025.117754. Online ahead of print.

PMID: 41265330

 

 

Genetic Determinants of Response to P2Y12 Inhibitors and Clinical Implications.

Cavallari LH, Coons JC.

Heart Fail Clin. 2026 Jan;22(1):77-88. doi: 10.1016/j.hfc.2025.09.002.

PMID: 41265989

 

 


Improved technical outcomes with converting thrombectomy techniques after failed first pass recanalization.

Matsukawa H, Matouk C, Uchida K, Al Kasab S, Sowlat MM, Elawady SS, Maier I, Jabbour P, Kim JT, Wolfe SQ, Rai AT, Starke RM, Psychogios MN, Samaniego EA, Arthur AS, Cuellar H, Howard BM, Romano DG, Tanweer O, Mascitelli JR, Fragata I, Polifka A, Osbun JW, Crosa RJ, Park MS, Levitt MR, Brinjikji W, Moss M, Williamson R, Navia P, Kan P, De Leacy RA, Chowdhry SA, Ezzeldin M, Spiotta AM, Yoshimura S, Alawieh AM.

J Neurointerv Surg. 2025 Nov 18;17(12):1333-1339. doi: 10.1136/jnis-2024-022071.

PMID: 39304195

 

 

A model-informed clinical trial simulation tool with a graphical user interface for Duchenne muscular dystrophy.

Kim J, Morales JF, Kang S, Klose M, Willcocks RJ, Daniels MJ, Belfiore-Oshan R, Walter GA, Rooney WD, Vandenborne K, Kim S.

CPT Pharmacometrics Syst Pharmacol. 2025 Nov;14(11):1765-1774. doi: 10.1002/psp4.13246. Epub 2024 Oct 3.

PMID: 39360574

 

 

Severe toxicity following genotype-guided reduced 5-FU dose in a heterozygous DPYD c.2846A>T carrier with stage III anal carcinoma: A case report.

Norris ML, DeRemer DL, Duarte JD, Kim GP, George TJ.

Cancer Chemother Pharmacol. 2025 Nov 21;95(1):109. doi: 10.1007/s00280-025-04833-1.

PMID: 41269318

 

 

Short communication: relationships between novel breeding values for heat tolerance and rectal temperature during heat stress in lactating Holstein cows.

Dikmen S, Vukasinovic N, Sánchez-Castro MA, Hansen PJ.

J Anim Sci. 2025 Jan 4;103:skaf386. doi: 10.1093/jas/skaf386.

PMID: 41212779

 

 

Cipaglucosidase alfa plus miglustat in Pompe disease: two non-ambulatory patients switching from high‑dose, high-frequency alglucosidase alfa.

Byrne BJ, Castelli J, Jain V, Das SS, Zhang J.

Neuromuscul Disord. 2025 Nov 5;56-57:106264. doi: 10.1016/j.nmd.2025.106264. Online ahead of print.

PMID: 41270519

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