UFGI Publication Round-Up: Week of 7/28/2025

Successful use of aflibercept for high cardiac output in hereditary hemorrhagic telangiectasia after failure of pazopanib and bevacizumab therapy.

Mathavan A, Mathavan A, Krekora U, Shukla K, Zumberg MS, Ataya A.

J Thromb Haemost. 2025 Aug;23(8):2651-2655. doi: 10.1016/j.jtha.2025.05.007. Epub 2025 May 14.

PMID: 40379104

 

 

Functional genomics and structural insights into maize aldo-keto reductase-4 family: Stress metabolism and substrate specificity in embryos.

Morais de Sousa S, Oliveira de Giuseppe P, Murakami MT, Guan JC, Saunders JW, Kiyota E, Santos ML, Schmelz EA, Yunes JA, Koch KE.

J Biol Chem. 2025 Jul;301(7):110404. doi: 10.1016/j.jbc.2025.110404. Epub 2025 Jun 20.

PMID: 40544997

 

 

Heterogeneous effects of sodium-glucose cotransporter-2 inhibitors compared to dipeptidyl peptidase-4 inhibitors on nephrolithiasis in older adults with type 2 diabetes.

Radwan RM, Huang W, Li Y, Shao H, Guo Y, Zhang Y, Fonseca V, Shi L, Huang Y, Schatz D, Bian J, Guo J.

Pharmacotherapy. 2025 Jul;45(7):426-434. doi: 10.1002/phar.70030. Epub 2025 Jun 17.

PMID: 40525798

 

 

A fair machine learning model to predict flares of systemic lupus erythematosus.

Li Y, Yao L, Lee YA, Huang Y, Merkel PA, Vina E, Yeh YY, Li Y, Allen JM, Bian J, Guo J.

JAMIA Open. 2025 Jul 26;8(4):ooaf072. doi: 10.1093/jamiaopen/ooaf072. eCollection 2025 Aug.

PMID: 40718760

 

 

The Surface-Topography Challenge: A Multi-Laboratory Benchmark Study to Advance the Characterization of Topography.

Pradhan A, Müser MH, Miller N, Abdelnabe JP, Afferrante L, Albertini D, Aldave DA, Algieri L, Ali N, Almqvist A, Amann T, Ares P, Balzer BN, Baugh L, Berberich EA, Björling M, Bobji MS, Bottiglione F, Brodmann B, Cai W, Carbone G, Carpick RW, Cassin F, Cayer-Barrioz J, Chowdhury MI, Ciavarella M, Cihan E, Huang D, Delplanque E, Deptula AJ, Descartes S, Dhinojwala A, Dienwiebel M, Dini D, Dunn AC, Edwards C, Eriten M, Esawi A, Espinosa-Marzal RM, Fang L, Fatemi A, Fidd C, Gabriel D, Gaslain F, Giordano G, Gómez-Herrero J, Gontard L, Gosvami NN, Greenwood G, Greiner C, Grejtak T, Haroun A, Hasan M, Hoppe S, Isa L, Jackson RL, Jang S, Johnson O, Kaiser F, Kalin M, Kalliorinne K, Karanjkar PH, Kim SH, Kinzelberger S, Klapetek P, Krick BA, Kumar C, Kumar N, Kumar S, LaMascus P, Larsson R, Laux P, Lee MJ, Lee PM, Lee W, Leriche C, Li J, Li Y, Li YS, Lubrecht TA, Lyashenko IA, Ma C, Ma T, Maaboudallah F, Mahmood S, Mangolini F, Marian M, Mazuyer D, Meng Y, Menga N, Miller T, Mulvihill DM, Najah M, Nečas D, Papadopoulos CI, Papangelo A, Pauli M, Persson BNJ, Peterson A, Pitenis AA, Podsiadlo P, Polajnar M, Popov VL, Požar T, Prasad A, Prieto G, Putignano C, Rahman MH, Ramisetti SB, Raumel S, Reyes IJ, Rodriguez N, Rodríguez Ripoll M, Rojacz H, Sainsot P, Samodurova A, Savio D, Scaraggi M, Schaefer F, Scherrer SW, Schulze KD, Shaffer KE, Sidebottom MA, Skaltsas D, Soni J, Spies C, Stachowiak GW, Steinhoff L, Strandwitz NC, Sun K, Tripathi S, Tuckart WR, Ugar S, Valtr M, Van Meter KE, Vdovak J, Vilhena JG, Violano G, Vorlaufer G, Walczak M, Weber B, Woloszynski T, Wolski M, Yadav A, Yastrebov VA, Yongjian M, Yuan L, Yus J, Zhang J, Zhang X, Zheng Q, Pastewka L, Jacobs TDB.

Tribol Lett. 2025;73(3):110. doi: 10.1007/s11249-025-02014-y. Epub 2025 Jul 26.

PMID: 40726540

 

 

Enacted HIV-Related Stigma Is Related to Sleep Disturbance Among People Living With HIV Through the Mediating Effect of Anxiety: The Florida Cohort Study, 2014-2018.

Ibañez GE, Ahmed S, Algarin AB, Nawfal ES, Li Y, Cohen RA, Cook RL.

J Assoc Nurses AIDS Care. 2025 Jul 29. doi: 10.1097/JNC.0000000000000574. Online ahead of print.

PMID: 40728219

 

 

Feasibility and Acceptability of a Psychological Intervention for Internalized Health-Related Stigma Among Adults With Chronic Health Conditions: Preliminary Investigation.

Pearl RL, Saunders D, Groshon LC, Li Y, Shonrock A, Puhl RM, Driscoll KA, Manavalan P, Gelfand JM, Wadden TA, Westen SC, Montanez-Wiscovich M, Lou XY.

JMIR Form Res. 2025 Jul 29;9:e69548. doi: 10.2196/69548.

PMID: 40729662

 

 

Altered Functional Brain Connectivity in Dyt1 Knock-in mouse models.

Adury RZ, Wilkes BJ, Girdhar P, Li Y, Vaillancourt DE.

Dystonia. 2025;4:13874. doi: 10.3389/dyst.2025.13874. Epub 2025 Feb 12.

PMID: 40735249

 

 

Correction: A scoping review of human papillomavirus related data system in China.

Li Y, Wang R, Zhang J, Chen YT, Zhan S, Guo Y, Wang W.

BMC Infect Dis. 2025 Aug 1;25(1):972. doi: 10.1186/s12879-025-11376-6.

PMID: 40750844

 

 

A fungal effector promotes infection via stabilizing a negative regulatory factor of chloroplast immunity.

Xiao K, Yang F, Cui W, Li A, Rollins JA, Guo J, Sun X, Wang F, Wang X, Xu X, Zhang Y, Zhang X, Liu J, Pan H.

Nat Commun. 2025 Jul 29;16(1):6970. doi: 10.1038/s41467-025-62326-4.

PMID: 40730546

 

 

Multi- and Transgenerational Histological and Transcriptomic Outcomes of Developmental TCDD Exposure in Zebrafish (Danio rerio) Ovary.

Paquette A, Cavaneau E, Haimbaugh A, Meyer DN, Akemann C, Dennis N, Baker TR.

Int J Mol Sci. 2025 Jul 16;26(14):6839. doi: 10.3390/ijms26146839.

PMID: 40725083

 

 

Video analysis reveals early signs of Bradykinesia in REM sleep behavior disorder and Parkinson’s disease.

Guarín DL, Acevedo G, Calonge C, Wong JK, McFarland NR, Ramirez-Zamora A, Vaillancourt DE.

NPJ Parkinsons Dis. 2025 Jul 30;11(1):222. doi: 10.1038/s41531-025-01082-0.

PMID: 40739299

 

 

Toward Bioactive Hydrogels: A Tunable Approach via Nucleic Acid-Collagen Complexation.

Pipis N, Duraivel S, Subramaniam V, Stewart KA, Angelini TE, Allen JB.

Regen Eng Transl Med. 2024 Dec;10(4):564-576. doi: 10.1007/s40883-024-00345-1. Epub 2024 May 28.

PMID: 40718684

 

 

Epigenomic diagnosis and prognosis of Acute Myeloid Leukemia.

Marchi F, Shastri VM, Marrero RJ, Nguyen NHK, Öttl A, Schade AK, Landwehr M, Krali O, Nordlund J, Ghavami M, Sckaff F, Mansinghka VK, Cao X, Slayton W, Starostik P, Cogle CR, Ribeiro RC, Rubnitz JE, Klco J, Elsayed A, Gamis AS, Triche TJ Jr, Ries R, Kolb EA, Aplenc R, Alonzo T, Pounds S, Meshinchi S, Lamba JK.

Nat Commun. 2025 Jul 29;16(1):6961. doi: 10.1038/s41467-025-62005-4.

PMID: 40730747

 

 

Single-cell multiomics identifies both shared and unique features of immune dysfunction in Parkinson’s disease and inflammatory bowel disease colon, plasma and stool.

Bolen ML, Buendia M, Shi J, Staley H, Kachergus JM, Efron PA, Park G, Nagpal R, Alvarez SD, Xue QS, McFarland NR, Zimmermann EM, Forsmark CE, Menees KB, Salas A, Thompson EA, Tansey MG.

bioRxiv [Preprint]. 2025 Jun 11:2025.04.29.651228. doi: 10.1101/2025.04.29.651228.

PMID: 40661410

 

 

Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases.

Zhang S, Shu H, Zhou J, Rubin-Sigler J, Yang X, Liu Y, Cooper-Knock J, Monte E, Zhu C, Tu S, Li H, Tong M, Ecker JR, Ichida JK, Shen Y, Zeng J, Tsao PS, Snyder MP.

Nat Biotechnol. 2025 Jul 25. doi: 10.1038/s41587-025-02725-6. Online ahead of print.

PMID: 40715455

 

 

A metagenomics-based approach to understanding the transmission of healthcare-associated antimicrobial resistance in Pakistan.

Asghar MU, Zhai Y, Liu T, Fan P, Ain NU, Zaidi AH, Tariq M, Mainar-Jaime RC, Jeong KC.

J Hazard Mater. 2025 Jul 29;496:139384. doi: 10.1016/j.jhazmat.2025.139384. Online ahead of print.

PMID: 40749656

 

 

Placental Malaria Induces Oxidative Stress in Human Syncytiotrophoblast.

Sarr D, Andrew AK, Shukla AK, Mwalimu S, Moore JM.

J Infect Dis. 2025 Jul 30;232(1):e174-e185. doi: 10.1093/infdis/jiaf243.

PMID: 40366119

 

 

Protocol for processing and analyzing multiplexed images improves lymphatic cell identification and spatial architecture in human tissue.

Smith JA, Bloss DT, Williams MD, Posgai AL, Brusko TM, Atkinson MA, Wasserfall CH, Brusko MA.

STAR Protoc. 2025 Jul 25;6(3):103976. doi: 10.1016/j.xpro.2025.103976. Online ahead of print.

PMID: 40714562

 

 

Osteoarthritis gene therapy: Expanding the scope of genetic therapies.

Evans CH, Ghivizzani SC, Keravala A, Chalberg TW, Robbins PD.

Mol Ther. 2025 Jul 28:S1525-0016(25)00555-6. doi: 10.1016/j.ymthe.2025.07.019. Online ahead of print.

PMID: 40730182

 

 

Psychiatric Genetics in Clinical Practice: Essential Knowledge for Mental Health Professionals.

Besterman AD, Alnor MA, Castaño M, DeLisi LE, Grice DE, Lohoff FW, Middeldorp CM, Müller DJ, Quattrone D, Nurnberger J Jr, Nurmi EL, Ross DA, Soda T, Schulze TG, Trost B, Vilella E, Yap CX, Zai G, Moreno-De-Luca D.

Am J Psychiatry. 2025 Aug 1;182(8):728-741. doi: 10.1176/appi.ajp.20240295. Epub 2025 Mar 26.

PMID: 40134266

 

 

Switching Enzyme Replacement Therapy for Late-Onset Pompe Disease From Alglucosidase Alfa to Cipaglucosidase Alfa Plus Miglustat: Post Hoc Effect Size Analysis of PROPEL.

Kushlaf H, Díaz-Manera J, Bratkovic D, Byrne BJ, Claeys KG, Clemens PR, Dimachkie MM, Kishnani PS, Laforêt P, Roberts M, Schoser B, Toscano A, Castelli J, Holdbrook F, Sitaraman Das S, Goldman M, Mozaffar T; PROPEL Study Group.

Muscle Nerve. 2025 Aug;72(2):230-239. doi: 10.1002/mus.28420. Epub 2025 May 7.

PMID: 40342075

 

 

Proteomic Responses of the Springtail Folsomia candida to Drought.

Wang Y, Slotsbo S, Bak SY, Martyniuk CJ, Holmstrup M.

Insects. 2025 Jul 9;16(7):707. doi: 10.3390/insects16070707.

PMID: 40725337

 

 

ACLY inhibition promotes tumour immunity and suppresses liver cancer.

Gautam J, Wu J, Lally JSV, McNicol JD, Fayyazi R, Ahmadi E, Oniciu DC, Heaton S, Newton RS, Rehal S, Bhattacharya D, Di Pastena F, Nguyen B, Valvano CM, Townsend LK, Banskota S, Batchuluun B, Jabile MJT, Payne A, Lu J, Desjardins EM, Kubota N, Tsakiridis EE, Mistry B, Aganostopoulos A, Houde V, Dansercoer A, Verschueren KHG, Savvides SN, Hammill JA, Bezverbnaya K, Muti P, Tsakiridis T, Dai W, Jiang L, Hoshida Y, Larché M, Bramson JL, Friedman SL, Verstraete K, Wang D, Steinberg GR.

Nature. 2025 Jul 30. doi: 10.1038/s41586-025-09297-0. Online ahead of print.

PMID: 40739358

 

 

Administration of Purified Alpha-1 Antitrypsin in Salt-Loaded Hypertensive 129Sv Mice Attenuates the Expression of Inflammatory Associated Proteins in the Kidney.

Nguyen VL, Dogan YE, Bala N, Galban ES, Song S, Alli AA.

Biomolecules. 2025 Jun 30;15(7):951. doi: 10.3390/biom15070951.

PMID: 40723823

 

 

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa.

Sun J, Wu J, Yuan Y, Fan L, Chua WLP, Ling YHS, Balamkundu S, Dwijapriya, Chay HSS, Begley TJ, de Crécy-Lagard V, Dziergowska A, Dedon PC.

Nucleic Acids Res. 2025 Jul 19;53(14):gkaf696. doi: 10.1093/nar/gkaf696.

PMID: 40716780

 

 

Recent Developments in Amber Biomolecular Simulations.

Case DA, Cerutti DS, Cruzeiro VWD, Darden TA, Duke RE, Ghazimirsaeed M, Giambaşu GM, Giese TJ, Götz AW, Harris JA, Kasavajhala K, Lee TS, Li Z, Lin C, Liu J, Miao Y, Salomon-Ferrrer R, Shen J, Snyder R, Swails J, Walker RC, Wang J, Wu X, Zeng J, Cheatham Iii TE, Roe DR, Roitberg A, Simmerling C, York DM, Nagan MC, Merz KM Jr.

J Chem Inf Model. 2025 Jul 29. doi: 10.1021/acs.jcim.5c01063. Online ahead of print.

PMID: 40728386

 

 

CYP2D6 Phenotypes and Emergency Department Visits Among Patients Receiving Opioid Treatment.

Nahid NA, McDonough CW, Wei YJ, Gong Y, Empey PE, Haddad A, Fillingim RB, Johnson JA.

JAMA Netw Open. 2025 Jul 1;8(7):e2523543. doi: 10.1001/jamanetworkopen.2025.23543.

PMID: 40720122

 

 

Concurrent Anterior Cerebral Artery and Middle Cerebral Artery Occlusions Predict Poor Neurological Outcome Despite Successful Thrombectomy in Anterior Circulation Stroke.

Hsu A, El Baba B, Eshraghi S, Giraudo F, Saberian S, Chalhoub R, Alawieh A, Chisango Z, Howard BM, Spiotta AM, Sowlat MM, Tong F, Akbik F, Pabaney A, Jabbour P, Tjoumakaris SI, Maier IL, Wolfe SQ, Rai A, Starke RM, Gory B, Psychogios MN, Shaban A, Goyal N, Kim JT, Yoshimura S, Kan P, De Leacy R, Fragata I, Polifka A, Osbun JW, Williamson R, Crosa RJ, Levitt MR, Moss M, Park MS, Casagrande W, Matouk C, Chowdhry SA, Cawley CM, Grossberg JA; , On behalf of the STAR Collaborators.

Neurosurgery. 2025 Jul 31. doi: 10.1227/neu.0000000000003669. Online ahead of print.

PMID: 40742212

 

 

Non-Traumatic Arytenoid Subluxation in a Patient With Hypermobile Ehlers-Danlos Syndrome.

Menton SM, Rhyner PA, Rutt AL, Fairweather D, Bruno KA, Gajarawala S, Knight DRT.

Laryngoscope. 2025 Aug 1. doi: 10.1002/lary.70005. Online ahead of print.

PMID: 40747778

 

 

Global climate cooling spurred skipper butterfly diversification.

Toussaint EFA, Condamine FL, Dos Santos De Carvalho AP, Plotkin DM, Ellis EA, Dexter KM, Earl C, Aduse-Poku K, Braby MF, Chiba H, Gott RJ, Maruyama K, Morais AB, Müller CJ, Peggie D, Sáfián S, Vila R, Warren AD, Yago M, Breinholt JW, Espeland M, Pierce NE, Lohman DJ, Kawahara AY.

Syst Biol. 2025 Jul 24:syaf029. doi: 10.1093/sysbio/syaf029. Online ahead of print.

PMID: 40717248

 

 

Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites.

Lam N, Angel JC, Buchholz BA, Lee Y, Weisberg SP, Brown BH, Davis-Porada J, Caron DP, Jensen IJ, Szabo PA, Ural BB, Wells SB, Kubota M, Matsumoto R, Brusko M, Brusko TM, Lu C, Yates AJ, Farber DL.

Immunity. 2025 Jul 25:S1074-7613(25)00310-3. doi: 10.1016/j.immuni.2025.07.001. Online ahead of print.

PMID: 40738109